Valerio Zerbi, Amalia Floriou Servou, Marija Markicevic, Yannick Vermeiren, Oliver Sturman, Mattia Privitera, Lukasvon Ziegler, Kim David Ferrari, Bruno Weber, Peter Paul De Deyn, Nicole Wenderoth, Johannes Bohacek
Neuron. 2019 Volume 103, Issue 4, 21 August, Pages 702-718.e5 https://doi.org/10.1016/j.neuron.2019.05.034
Authors studied the effect of Locus Coeruleus (LC) stimulation on large-scale functional connectivity. Over stimulation of LC rapidly interrupted ongoing behavior and strongly increases brain-wide connectivity, with the most profound effects in the salience and amygdala networks. Authors proposed that noradrenergic molecular changes in large-scale network connectivity are critical for optimizing neural processing in the context of increased vigilance and threat detection.