The locus coeruleus:
at the crossroad of dementia syndromes

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

Valerio Zerbi, Amalia Floriou Servou, Marija Markicevic, Yannick Vermeiren, Oliver Sturman, Mattia Privitera, Lukasvon Ziegler, Kim David Ferrari, Bruno Weber, Peter Paul De Deyn, Nicole Wenderoth, Johannes Bohacek

Neuron. 2019 Volume 103, Issue 4, 21 August, Pages 702-718.e5

Authors studied the effect of Locus Coeruleus (LC) stimulation on large-scale functional connectivity. Over stimulation of LC rapidly interrupted ongoing behavior and strongly increases brain-wide connectivity, with the most profound effects in the salience and amygdala networks. Authors proposed that noradrenergic molecular changes in large-scale network connectivity are critical for optimizing neural processing in the context of increased vigilance and threat detection.